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SB 203580 hydrochloride

Product Specifications

CAS Number

869185-85-3

Target

Mitophagy, Autophagy, p38 MAPK, Src

Related Pathways

MAPK, Autophagy, Angiogenesis, Tyrosine Kinase/Adaptors

Purity

0.9779

Bioactivity

SB 203580 hydrochloride (Adezmapimod hydrochloride) is a selective, ATP-competitive p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy and inhibits SAPK2a/p38, SAPK2b/p38β2, LCK, GSK3β, and PKBα. SB 203580 hydrochloride has been shown to be useful in antiretroviral therapy. 203580 hydrochloride inhibits amphoteric mechanical anomalous pain in a mouse model of antiretroviral-induced neuropathic pain.

Smiles

Cl.O=S(C=1C=CC(=CC1)C2=NC(C=3C=CN=CC3)=C(N2)C=4C=CC(F)=CC4)C

Molecular Formula

C21H17ClFN3OS

Molecular Weight

413.9

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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