SB 203580 hydrochloride
Product Specifications
CAS Number
869185-85-3
Target
Mitophagy, Autophagy, p38 MAPK, Src
Related Pathways
MAPK, Autophagy, Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9779
Bioactivity
SB 203580 hydrochloride (Adezmapimod hydrochloride) is a selective, ATP-competitive p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy and inhibits SAPK2a/p38, SAPK2b/p38β2, LCK, GSK3β, and PKBα. SB 203580 hydrochloride has been shown to be useful in antiretroviral therapy. 203580 hydrochloride inhibits amphoteric mechanical anomalous pain in a mouse model of antiretroviral-induced neuropathic pain.
Smiles
Cl.O=S(C=1C=CC(=CC1)C2=NC(C=3C=CN=CC3)=C(N2)C=4C=CC(F)=CC4)C
Molecular Formula
C21H17ClFN3OS
Molecular Weight
413.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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