IWP-3
Product Specifications
CAS Number
687561-60-0
Target
Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling, Stem Cells
Purity
0.9838
Bioactivity
IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].
Smiles
Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccc(F)cc3)sc2c1
Molecular Formula
C22H17FN4O2S3
Molecular Weight
484.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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