Vandetanib hydrochloride
Product Specifications
CAS Number
524722-52-9
Target
Apoptosis, VEGFR, Autophagy, Others
Related Pathways
Apoptosis, Autophagy, Tyrosine Kinase/Adaptors, Others, Angiogenesis
Bioactivity
Vandetanib hydrochloride (D6474 hydrochloride) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity with an IC50 of 40 nM. It also exhibits activity against VEGFR3/FLT4 tyrosine kinase activity (IC50 = 110 nM) and EGFR/HER1 (IC50 = 500 nM) [1].
Smiles
Cl.COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Molecular Formula
C22H25BrClFN4O2
Molecular Weight
511.81
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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