AT7867 dihydrochloride
Product Specifications
CAS Number
1431697-86-7
Target
Akt|||Others|||PKA|||S6 Kinase
Related Pathways
PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors|||MAPK|||Others|||Cytoskeletal Signaling
Bioactivity
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA kinase, with IC50 values of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively. It induces pharmacodynamic changes and inhibits human tumor xenograft growth.
Smiles
Cl.Cl.Clc1ccc(cc1)C1(CCNCC1)c1ccc(cc1)-c1cn[nH]c1
Molecular Formula
C20H22Cl3N3
Molecular Weight
410.77
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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