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AT7867 dihydrochloride

Product Specifications

CAS Number

1431697-86-7

Target

Akt|||Others|||PKA|||S6 Kinase

Related Pathways

PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors|||MAPK|||Others|||Cytoskeletal Signaling

Bioactivity

AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA kinase, with IC50 values of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively. It induces pharmacodynamic changes and inhibits human tumor xenograft growth.

Smiles

Cl.Cl.Clc1ccc(cc1)C1(CCNCC1)c1ccc(cc1)-c1cn[nH]c1

Molecular Formula

C20H22Cl3N3

Molecular Weight

410.77

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Product Datasheet

https://www.targetmol.com/attachment/DataSheet/D98614FE-769D-4790-B5E6-DBFD19DE75AC/T21624

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