Surzebiclimab
Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) . Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer[1].
Product Specifications
CAS Number
[2342597-90-2]
Product Name Alternative
BGB-A425
UNSPSC
12352203
Target
Mucin
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/surzebiclimab.html
Purity
95.00
Solubility
10 mM in DMSO
Smiles
[Surzebiclimab]
Molecular Weight
(145.72 kDa)
References & Citations
[1]Tong Z, et, al. Abstract 2628: BGB-A425: a humanized anti-human Tim-3 antibody that exhibits strong immune cell activation. Cancer Res. 2017;77: (13_Supplement) :2628.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3
Available Sizes
Curated Selection
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