KN-93 hydrochloride
Product Specifications
CAS Number
1956426-56-4
Target
CaMK, Autophagy
Related Pathways
Autophagy, Neuroscience
Purity
0.9999
Bioactivity
KN-93 hydrochloride is a cell-permeable, reversible, and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. KN-93 hydrochloride induces G1 cell cycle arrest in 95% of treated cells after two days, with the arrest being reversible; one day after KN-93 withdrawal, a peak of cells progresses into S and G2-M phases, providing a robust tool for cell cycle regulation studies and mechanistic investigation of CaMKII-dependent signaling.
Smiles
Cl.O=S(=O)(C1=CC=C(OC)C=C1)N(C=2C=CC=CC2CN(C)CC=CC3=CC=C(Cl)C=C3)CCO
Molecular Formula
C26H30Cl2N2O4S
Molecular Weight
537.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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