TAK-441
Product Specifications
CAS Number
1186231-83-3
Target
Hedgehog/Smoothened
Related Pathways
Stem Cells, GPCR/G Protein
Purity
0.9982
Bioactivity
TAK-441 is an orally active inhibitor of Hedgehog signaling (IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth.
Smiles
O(CC(F)(F)F)C=1C2=C(N(C)C1C(NC3CCN(C(CO)=O)CC3)=O)C=C(CC)N(CC(=O)C4=CC=CC=C4)C2=O
Molecular Formula
C28H31F3N4O6
Molecular Weight
576.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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