R306465
Product Specifications
CAS Number
604769-01-9
Target
Apoptosis, HDAC
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis
Purity
0.9964
Bioactivity
R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies.
Smiles
O=C(NO)C1=CN=C(N=C1)N2CCN(CC2)S(=O)(=O)C=3C=CC=4C=CC=CC4C3
Molecular Formula
C19H19N5O4S
Molecular Weight
413.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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