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Amsilarotene

Product Specifications

CAS Number

125973-56-0

Target

Apoptosis, Retinoid Receptor, CDK

Related Pathways

Cell Cycle/Checkpoint, Metabolism, Apoptosis

Purity

0.9927

Bioactivity

Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.

Smiles

C[Si](C)(C)c1cc(cc(c1)[Si](C)(C)C)C(=O)Nc1ccc(cc1)C(O)=O

Molecular Formula

C20H27NO3Si2

Molecular Weight

385.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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