Amsilarotene
Product Specifications
CAS Number
125973-56-0
Target
Apoptosis|||Retinoid Receptor|||CDK
Related Pathways
Cell Cycle/Checkpoint|||Metabolism|||Apoptosis
Purity
0.9927
Bioactivity
Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.
Smiles
C[Si](C)(C)c1cc(cc(c1)[Si](C)(C)C)C(=O)Nc1ccc(cc1)C(O)=O
Molecular Formula
C20H27NO3Si2
Molecular Weight
385.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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