Trametinib
Product Specifications
CAS Number
871700-17-3
Target
Apoptosis, MEK, Autophagy
Related Pathways
Autophagy, Apoptosis, MAPK
Purity
0.9996
Bioactivity
Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.
Smiles
N(C1=C2C(N(C(=O)N(C2=O)C3CC3)C4=CC(NC(C)=O)=CC=C4)=C(C)C(=O)N1C)C5=C(F)C=C(I)C=C5
Molecular Formula
C26H23FIN5O4
Molecular Weight
615.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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