Ixazomib
Product Specifications
CAS Number
1072833-77-2
Target
Proteasome, Caspase, Autophagy
Related Pathways
Proteases/Proteasome, Apoptosis, Autophagy, Ubiquitination
Purity
0.9977
Bioactivity
Ixazomib (MLN2238), a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites (IC50: 31/3500 nM) .
Smiles
CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
Molecular Formula
C14H19BCl2N2O4
Molecular Weight
361.03
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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