Venetoclax
Product Specifications
CAS Number
1257044-40-8
Target
Autophagy, Bcl-2 Family
Related Pathways
Autophagy, Apoptosis
Purity
0.9997
Bioactivity
Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM) . Venetoclax induces autophagy and apoptosis.
Smiles
O=C(C1=CC=C(N2CCN(CC2)CC3=C(CC(C)(CC3)C)C4=CC=C(Cl)C=C4)C=C1OC5=CC6=C(NC=C6)N=C5)NS(=O)(C7=CC=C(C([N+]([O-])=O)=C7)NCC8CCOCC8)=O
Molecular Formula
C45H50ClN7O7S
Molecular Weight
868.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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