Danusertib
Product Specifications
CAS Number
827318-97-8
Target
Autophagy, Aurora Kinase, c-RET, FGFR, Bcr-Abl, Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors, Autophagy, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Cytoskeletal Signaling, Angiogenesis, Apoptosis
Purity
0.9879
Bioactivity
Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed.
Smiles
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1
Molecular Formula
C26H30N6O3
Molecular Weight
474.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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