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Danusertib

Product Specifications

CAS Number

827318-97-8

Target

Autophagy, Aurora Kinase, c-RET, FGFR, Bcr-Abl, Trk receptor

Related Pathways

Tyrosine Kinase/Adaptors, Autophagy, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Cytoskeletal Signaling, Angiogenesis, Apoptosis

Purity

0.9879

Bioactivity

Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed.

Smiles

CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1

Molecular Formula

C26H30N6O3

Molecular Weight

474.55

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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