TH287 hydrochloride
Product Specifications
CAS Number
1638211-05-8
Target
DNA/RNA Synthesis, MTH1
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Purity
>99.99%
Bioactivity
TH287 is a selective MTH1 inhibitor (IC50 : 0.8 nM) . It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
Smiles
NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl
Molecular Formula
C11H11Cl3N4
Molecular Weight
305.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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