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Semaxinib

Product Specifications

CAS Number

204005-46-9

Target

VEGFR

Related Pathways

Angiogenesis|||Tyrosine Kinase/Adaptors

Purity

0.9984

Bioactivity

Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 ?M), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFR?, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.

Smiles

C(=C1C=2C(NC1=O)=CC=CC2)C=3NC(C)=CC3C

Molecular Formula

C15H14N2O

Molecular Weight

238.28

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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