UbcH5c-IN-1
UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent[1].
Product Specifications
CAS Number
2123480-72-6
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/UbcH5c-IN-1.html
Purity
99.84
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
BrC1=CC=CC=C1COC2=C(C)C([C@H](OC(C3=C)=O)[C@H]3CC4)=C4C(C)=C2
Molecular Formula
C22H21BrO3
Molecular Weight
413.30
References & Citations
[1]Chen H, et al. Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives. J Med Chem. 2017 Aug 24;60 (16) :6828-6852.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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