Amakusamine
Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL) -induced formation of multinuclear osteoclasts with an IC50 value of 10.5 μM in RAW264.7 cells.
Product Specifications
CAS Number
2923661-84-9
UNSPSC
12352005
Target
RANKL/RANK
Type
Natural Products
Related Pathways
NF-κB
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/amakusamine.html
Solubility
10 mM in DMSO
Smiles
BrC1=C2OCOC2=C(C3=C1C=CN3)Br
Molecular Formula
C9H5Br2NO2
Molecular Weight
318.95
References & Citations
[1]Maeyama Y, et al. Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts. J Nat Prod. 2021 Oct 22;84 (10) :2738-2743.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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