Dacomitinib hydrate
Product Specifications
CAS Number
1042385-75-0
Target
EGFR
Related Pathways
JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9952
Bioactivity
Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.
Smiles
O.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1
Molecular Formula
C24H27ClFN5O3
Molecular Weight
487.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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