CL 316243

CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors[1].CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate[2]. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence[3].

Product Specifications

CAS Number

[138908-40-4]

Product Name Alternative

Saponin

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cl-316243.html

Purity

99.98

Solubility

DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 4.55 mg/mL (ultrasonic; warming; adjust pH to 12 with 1 M NaOH; heat to 60°C)

Smiles

O=C(C1(C(O[Na])=O)OC2=CC=C(C[C@H](NC[C@@H](C3=CC=CC(Cl)=C3)O)C)C=C2O1)O[Na]

Molecular Formula

C20H18ClNNa2O7

Molecular Weight

465.79

References & Citations

[1]Bloom JD, et al. Disodium (R, R) -5-[2-[[2- (3-chlorophenyl) -2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243) . A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.J Med Chem. 1992 Aug 7;35 (16) :3081-4.|[2]Shin W, et al. Impaired adrenergic agonist-dependent beige adipocyte induction in obese mice.J Vet Med Sci. 2019 Jun 6;81 (6) :799-807.|[3]Woods M, et al. Efficacy of the beta3-adrenergic receptor agonist CL-316243 on experimental bladder hyperreflexia and detrusor instability in the rat. J Urol. 2001 Sep;166 (3) :1142-7.