Ciglitazone
Product Specifications
CAS Number
74772-77-3
Target
Apoptosis|||p38 MAPK|||PPAR
Related Pathways
Metabolism|||DNA Damage/DNA Repair|||MAPK|||Apoptosis
Purity
0.9984
Bioactivity
Ciglitazone (ADD 3878) is a potent and selective PPAR? agonist (EC50: 3 ?M) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF) . Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia.
Smiles
CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1
Molecular Formula
C18H23NO3S
Molecular Weight
333.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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