SB 224289
Product Specifications
CAS Number
180083-23-2
Target
Others|||5-HT Receptor
Related Pathways
GPCR/G Protein|||Neuroscience|||Others
Bioactivity
SB 224289 is a selective antagonist of 5-HT1B receptor with pKi of 8.2. It is a centrally active following oral administration in vivo. SB 224289 displays 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays.
Smiles
C(=O)(N1C=2C=C3C4(COC3=CC2CC1)CCN(C)CC4)C5=CC=C(C=C5)C6=C(C)C=C(C=C6)C=7N=C(C)ON7
Molecular Formula
C32H32N4O3
Molecular Weight
520.62
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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