8-Chloroadenosine
Product Specifications
CAS Number
34408-14-5
Target
Autophagy, AMPK
Related Pathways
Autophagy, Chromatin/Epigenetic, PI3K/Akt/mTOR signaling
Purity
0.9984
Bioactivity
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Chloroadenosine (NSC-354258) is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226, and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. 8-Chloroadenosine (NSC-354258) has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.
Smiles
ClC=1N(C=2C(N1)=C(N)N=CN2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
Molecular Formula
C10H12ClN5O4
Molecular Weight
301.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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