PF-06273340
Product Specifications
CAS Number
1402438-74-7
Target
Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors
Purity
0.98
Bioactivity
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM) . PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 x 10 6 cm s 1) .
Smiles
C(=O)(C=1C=2C(N(C(CO)(C)C)C1)=NC(N)=NC2)C=3C=C(NC(CC4=CC=C(Cl)C=N4)=O)C=NC3
Molecular Formula
C23H22ClN7O3
Molecular Weight
479.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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