NBD-14189
Product Specifications
UNSPSC Description
NBD-14189 is a potent HIV-1 entry antagonist with an IC50?of 89 nM against the HIV-1HXB2?pseudovirus. NBD-14189 binds to HIV-1 gp120 and shows potent antiviral activity (EC50[1][2].
Target Antigen
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nbd-14189.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(C(F)(F)F)C=CC(C2=CC=C(C(N[C@@H](CN)C3=NC(CO)=CS3)=O)N2)=C1
Molecular Weight
428.40
References & Citations
[1]Francesca Curreli, et al. Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120. Eur J Med Chem. 2018 Jun 25;154:367-391.|[2]Natalie Losada, et al. HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites. J Med Chem. 2021 Nov 25;64(22):16530-16540.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139985/NBD-14189-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139985/NBD-14189-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2234273-72-2
Available Sizes
Curated Selection
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