2-Methacryloyloxyethyl phosphorylcholine

2-Methacryloyloxyethyl phosphorylcholine is a polymer monomer containing a phospholipid polar group. 2-Methacryloyloxyethyl phosphorylcholine polymers modify the surface properties of materials and reduce protein-surface interactions, reduce IL-8 production, inhibit cell, Staphylococcus aureus, and Porphyromonas gingivalis adhesion. 2-Methacryloyloxyethyl phosphorylcholine is used in the study of medical device-associated infections, periodontitis, and dental caries[1][2][3][4].

Product Specifications

CAS Number

[67881-98-5]

UNSPSC

12352200

Hazard Statement

H317

Target

Biochemical Assay Reagents; Interleukin Related

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation; Others

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-methacryloyloxyethyl-phosphorylcholine.html

Purity

99.14

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

C=C(C)C(OCCOP(OCC[N+](C)(C)C)([O-])=O)=O

Molecular Formula

C11H22NO6P

Molecular Weight

295.27

Precautions

H317

References & Citations

[1]Ishihara K, et al. Inhibition of fibroblast cell adhesion on substrate by coating with 2-methacryloyloxyethyl phosphorylcholine polymers. J Biomater Sci Polym Ed. 1999;10 (10) :1047-61.|[2]Yumoto H, et al. Anti-inflammatory and protective effects of 2-methacryloyloxyethyl phosphorylcholine polymer on oral epithelial cells. J Biomed Mater Res A. 2015 Feb;103 (2) :555-63.|[3]Jang K, et al. An efficient surface modification using 2-methacryloyloxyethyl phosphorylcholine to control cell attachment via photochemical reaction in a microchannel. Lab Chip. 2010 Aug 7;10 (15) :1937-45. |[4]Kaneko T, et al. 2-Methacryloyloxyethyl Phosphorylcholine Polymer Coating Inhibits Bacterial Adhesion and Biofilm Formation on a Suture: An In Vitro and In Vivo Study. Biomed Res Int. 2020 Oct 1;2020:5639651.