Dabrafenib
Product Specifications
CAS Number
1195765-45-7
Target
Raf
Related Pathways
MAPK
Purity
>99.99%
Bioactivity
Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma.
Smiles
CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Molecular Formula
C23H20F3N5O2S2
Molecular Weight
519.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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