Kobe0065
Product Specifications
CAS Number
436133-68-5
Target
Raf, Ras, Apoptosis
Related Pathways
GPCR/G Protein, Apoptosis, MAPK
Purity
>99.99%
Bioactivity
Kobe0065 is a novel and effective small-molecule compound that inhibits the Ras-Raf interaction by structure-based drug design (SBDD) ; it displays potent activity, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
Smiles
Cc1ccc(NC(=S)NNc2c(cc(cc2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)cc1Cl
Molecular Formula
C15H11ClF3N5O4S
Molecular Weight
449.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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