SNIPER (ABL) -058
Product Specifications
CAS Number
2222354-61-0
Target
SNIPERs, Others, Bcr-Abl
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Others, PROTAC, Cytoskeletal Signaling
Bioactivity
SNIPER (ABL) -058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 10 μM[1].
Smiles
C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCC(=O)N5CCN(CC6=CC=C(C(NC7=CC(NC=8N=C(C=CN8)C=9C=CC=NC9)=C(C)C=C7)=O)C=C6)CC5)=CC=C4)=CS3)[H]
Molecular Formula
C62H75N11O9S
Molecular Weight
1150.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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