SNIPER (ABL) -049
Product Specifications
Target
Others, SNIPERs, Bcr-Abl
Related Pathways
Angiogenesis, Others, Cytoskeletal Signaling, PROTAC, Tyrosine Kinase/Adaptors
Bioactivity
SNIPER (ABL) -049, a compound that conjugates Imatinib (ABL inhibitor) with Bestatin (IAP ligand) through a linker, effectively reduces BCR-ABL protein levels, demonstrating a DC50 of 100 μM[1].
Smiles
CC1=CC=C(NC(C2=CC=C(CN3CCN(C(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC4=CC=CC=C4)N)=O)=O)=O)CC3)C=C2)=O)C=C1NC5=NC=CC(C6=CC=CN=C6)=N5
Molecular Formula
C52H66N10O8
Molecular Weight
959.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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