SNIPER (ABL) -039
Product Specifications
CAS Number
2222354-29-0
Target
SNIPERs, Others, Bcr-Abl
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Others, Cytoskeletal Signaling, PROTAC
Bioactivity
SNIPER (ABL) -039, conjugating Dasatinib (ABL inhibitor) to an LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM for ABL, 10 nM for cIAP1, 12 nM for cIAP2, and 50 nM for XIAP[1].
Smiles
C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCC(=O)N5CCN(CC5)C=6C=C(NC=7SC(C(NC8=C(C)C=CC=C8Cl)=O)=CN7)N=C(C)N6)=CC=C4)=CS3)[H]
Molecular Formula
C54H68ClN11O9S2
Molecular Weight
1114.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
302698 200 µL
RECQL (ATP-Dependent DNA Helicase Q1, DNA Helicase, RecQ-like Type 1, RecQ1, DNA-Dependent ATPase Q1, RecQ Protein-like 1, RECQL, RECQ1, RECQL1)
Sign In for Pricing
View Details YP-W27967-01 48 Tests
Mouse Parvovirus IgG antibody (CPV-IgG) ELISA Kit
Sign In for Pricing
View Details YP-W27967-02 96 Tests
Mouse Parvovirus IgG antibody (CPV-IgG) ELISA Kit
Sign In for Pricing
View Details T8665-19D 1 mg
Troponin I, Cardiac, aa87-91 (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817, TNNC1, Troponin I Type 3 Cardiac, TNNI3)
Sign In for Pricing
View Details MBS451256-01 48 Tests
Mouse Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) ELISA Kit
Sign In for Pricing
View Details