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SNIPER (ABL) -033

Product Specifications

CAS Number

2222354-18-7

Target

SNIPERs|||Others|||Bcr-Abl

Related Pathways

Others|||Angiogenesis|||PROTAC|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors

Bioactivity

SNIPER (ABL) -033, a compound that conjugates HG-7-85-01 (ABL inhibitor) to a LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 ?M[1].

Smiles

C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCC(NC=5SC=6C(N5)=CC=C(N6)C7=CC(C(NC8=CC(C(F)(F)F)=C(CN9CCN(CC)CC9)C=C8)=O)=CC=C7)=O)=CC=C4)=CS3)[H]

Molecular Formula

C61H73F3N10O9S2

Molecular Weight

1211.42

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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