SNIPER (ABL) -024

Product Specifications

CAS Number

2222355-77-1

Target

SNIPERs|||Others|||Bcr-Abl

Related Pathways

Cytoskeletal Signaling|||PROTAC|||Tyrosine Kinase/Adaptors|||Others|||Angiogenesis

Bioactivity

SNIPER (ABL) -024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 5?M[1].

Smiles

C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCCNC(=O)C5=CC(=CC=C5)C=6C=C(NC7=CC=C(OC(F)(F)F)C=C7)N=CN6)=CC=C4)=CS3)[H]