SNIPER (ABL) -019
Product Specifications
Target
Bcr-Abl, Others, SNIPERs
Related Pathways
Tyrosine Kinase/Adaptors, Others, PROTAC, Cytoskeletal Signaling, Angiogenesis
Bioactivity
SNIPER (ABL) -019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 μM[1].
Smiles
CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCNC([C@H](C(C5=CC=CC=C5)C6=CC=CC=C6)NC([C@H]7N(C([C@@H](NC([C@H](C)NC)=O)C8CCCCC8)=O)CCC7)=O)=O)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
Molecular Formula
C60H77ClN12O9S
Molecular Weight
1177.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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