SD-36
Product Specifications
CAS Number
2429877-44-9
Target
PROTACs|||Apoptosis|||STAT
Related Pathways
JAK/STAT signaling|||Stem Cells|||PROTAC|||Apoptosis
Purity
>99.99%
Bioactivity
SD-36 is a selective and efficient STAT3 protein degrader (Kd=~50 nM) with antitumor activity that promotes growth inhibition and induces apoptosis by inhibiting Mcl-1 in gliomas.SD-36 inhibits the transcriptional activity of STAT3.
Smiles
C(N[C@H](C(NC(C1=CC=CC=C1)C2=CC=CC=C2)=O)CCC(N)=O)(=O)[C@H]3N4[C@](CC3)(CCN(C(CCCCCC#CC5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5)=O)C[C@H](NC(=O)C8=CC=9C(N8)=CC=C(C(P(=O)(O)O)(F)F)C9)C4=O)[H]
Molecular Formula
C59H62F2N9O12P
Molecular Weight
1158.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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