(S, R, S) -AHPC-C2-PEG4-N3
Product Specifications
Target
Others, E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC, Others
Bioactivity
(S, R, S) -AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that combines the (S, R, S) -AHPC-based VHL ligand with a 4-unit polyethylene glycol (PEG) linker, used in PROteolysis TAgeting Chimera (PROTAC) technology. This compound aids in the formation of vRucaparib-TP4, a potent PARP1 degrader with a half-maximal degrading concentration (DC50) of 82 nM[1].
Smiles
CC(C)([C@H](NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)C
Molecular Formula
C33H49N7O8S
Molecular Weight
703.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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