PROTAC BRD2/BRD4 degrader-1
Product Specifications
Target
PROTACs, Epigenetic Reader Domain, Others
Related Pathways
PROTAC, Chromatin/Epigenetic, Others
Bioactivity
PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination compared to BRD3. It effectively suppresses solid tumors with minimal cytotoxic effects and comprises a BET inhibitor, a connecting linker, and thalidomide as the ligand for cereblon (CRBN) /cullin 4A[1].
Smiles
O=C(NCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC4=CC5=C(NS(=O)(C6=CC=CC=C6OC)=O)C=CC(N(C)C7=O)=C5C7=C4
Molecular Formula
C39H38N6O9S
Molecular Weight
766.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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