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Rac-Belinostat

Product Specifications

CAS Number

414864-00-9

Target

Autophagy, HDAC

Related Pathways

Autophagy, Chromatin/Epigenetic, DNA Damage/DNA Repair

Purity

0.9996

Bioactivity

Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.

Smiles

ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1

Molecular Formula

C15H14N2O4S

Molecular Weight

318.35

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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