Rac-Belinostat
Product Specifications
CAS Number
414864-00-9
Target
Autophagy, HDAC
Related Pathways
Autophagy, Chromatin/Epigenetic, DNA Damage/DNA Repair
Purity
0.9996
Bioactivity
Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
Smiles
ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1
Molecular Formula
C15H14N2O4S
Molecular Weight
318.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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