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PAC

Product Specifications

CAS Number

2158322-33-7

Target

Estrogen Receptor/ERR, PROTAC-Linker Conjugates for PAC

Related Pathways

Endocrinology/Hormones, Antibody-drug Conjugate/ADC Related

Bioactivity

PAC is a chemical conjugate consisting of an ADCs linker and PROTACs linked to an antibody. When PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ERα) in comparison to PROTAC alone.

Smiles

CCC(=C(c1ccc(OCCN(C)C(=O)COCCOCCNC(=O)c2ccc(cc2)C(=O)N2[C@@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4ccccc34)c3ccc(cc23)C#N)cc1)c1ccc(OCc2ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)cc2)cc1)c1ccccc1 |w:3.3,c:112|

Molecular Formula

C94H107N13O16

Molecular Weight

1674.965

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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