Momelotinib
Product Specifications
CAS Number
1056634-68-4
Target
JAK|||Autophagy|||Apoptosis
Related Pathways
JAK/STAT signaling|||Chromatin/Epigenetic|||Stem Cells|||Angiogenesis|||Apoptosis|||Tyrosine Kinase/Adaptors|||Autophagy
Purity
0.9956
Bioactivity
Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells.
Smiles
O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Molecular Formula
C23H22N6O2
Molecular Weight
414.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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