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Mc-Val-Cit-PAB-Cl

Product Specifications

CAS Number

1639351-92-0

Target

ADC Linker

Related Pathways

Antibody-drug Conjugate/ADC Related

Purity

0.9979

Bioactivity

Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.

Smiles

[C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@H](C)C)=O)(C(NC2=CC=C(CCl)C=C2)=O)CCCNC(N)=O

Molecular Formula

C28H39ClN6O6

Molecular Weight

591.1

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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