Mc-Val-Cit-PAB-Cl
Product Specifications
CAS Number
1639351-92-0
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Purity
0.9979
Bioactivity
Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.
Smiles
[C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@H](C)C)=O)(C(NC2=CC=C(CCl)C=C2)=O)CCCNC(N)=O
Molecular Formula
C28H39ClN6O6
Molecular Weight
591.1
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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