KB02-SLF
Product Specifications
Target
FKBP, PROTACs
Related Pathways
PROTAC, Autophagy, Immunology/Inflammation, Apoptosis
Bioactivity
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, also known as a molecular glue, that facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, thus forming KB02-SLF[1] and enhancing the longevity of protein degradation in biological systems.
Smiles
O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCOCCOCCNC(COC3=CC4=C(N(C(CCl)=O)CCC4)C=C3)=O)=O)=C2)CCC5=CC=C(OC)C(OC)=C5
Molecular Formula
C50H65ClN4O12
Molecular Weight
949.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6277282-01 0.1 mL
BACH2, ID (BACH2, Transcription regulator protein BACH2, BTB and CNC homolog 2) (MaxLight 750)
Sign In for Pricing
View Details MBS6277282-02 5x 0.1 mL
BACH2, ID (BACH2, Transcription regulator protein BACH2, BTB and CNC homolog 2) (MaxLight 750)
Sign In for Pricing
View Details MBS6262322-01 0.1 mL
Fatty Acid Binding Protein, Cardiac (FABP) (HRP)
Sign In for Pricing
View Details MBS6262322-02 5x 0.1 mL
Fatty Acid Binding Protein, Cardiac (FABP) (HRP)
Sign In for Pricing
View Details 
KLR6529 1x 96 Well
GENLISA Rat SCD86/B7-2 (Soluble Cluster of Differentiation 41 Ligand) ELISA
Sign In for Pricing
View Details