K-Ras ligand-Linker Conjugate 2
Product Specifications
Target
Others, Target Protein Ligand-Linker Conjugate
Related Pathways
Others, PROTAC
Bioactivity
K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in synthesizing PROTAC K-Ras Degrader-1, a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
Smiles
NCCOCCOCCOCCO[C@H]1CN(C)[C@H](COC2=NC3=C(CCN(C4=CC=CC5=C4C=CC=C5)C3)C(N6CCN(C(OCC7=CC=CC=C7)=O)[C@@H](CC#N)C6)=N2)C1
Molecular Formula
C45H58N8O7
Molecular Weight
822.99
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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