K-Ras ligand-Linker Conjugate 1
Product Specifications
Target
Others, Target Protein Ligand-Linker Conjugate
Related Pathways
Others, PROTAC
Bioactivity
K-Ras ligand-Linker Conjugate 1 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, facilitating the recruitment of E3 ligases VHL, CRBN, MDM2, and IAP. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells [1].
Smiles
O=C(N1CCOCCOCCOCCO[C@@H]2C[C@@H](COC3=NC4=C(CCNC4)C(N5CCN(C(OCC6=CC=CC=C6)=O)[C@@H](CC#N)C5)=N3)N(C)C2)C7=C(C=CC=C7)C1=O
Molecular Formula
C43H54N8O9
Molecular Weight
826.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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