Edoxaban M4

Edoxaban M4, an active metabolite of Edoxaban, shows reproducible, but concentration-dependent matrix effects. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor [1][2].

Product Specifications

CAS Number

[834919-19-6]

Product Name Alternative

D21-2393

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/edoxaban-m4.html

Purity

99.13

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)[C@@H]1C[C@H]([C@H](CC1)NC(C(NC2=NC=C(C=C2)Cl)=O)=O)NC(C3=NC4=C(CN(CC4)C)S3)=O

Molecular Formula

C22H25ClN6O5S

Molecular Weight

520.99

Precautions

H302, H315, H319, H335

References & Citations

[1]Romain Siriez, et al. Importance of measuring pharmacologically active metabolites of edoxaban: development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method. J Thromb Thrombolysis. 2020 Apr;49 (3) :395-403.|[2]Kathrin I Foerster, et al. Simultaneous quantification of direct oral anticoagulants currently used in anticoagulation therapy. J Pharm Biomed Anal. 2018 Jan 30;148:238-244.